7 February 2007 Optical properties reconstruction of layered tissue and the experimental demonstration
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A method for rapid reconstruction of optical properties, such as the absorption and scattering coefficients of the thin layered tissue from diffuse reflection, is introduced. As the diffusion-approximation-based approaches are not applicable in the case of small source-detector separation, Monte-Carlo (MC) method is chosen as the forward model to simulate the photon migration in the transport regime. A flexible and fast perturbation model of diffuse reflectance has been developed for the extraction of the information of photon migration in tissue from MC model. With the derived photon migration information, the inverse problem for obtaining the optical properties was solved by a Gauss-Newton nonlinear least-squares algorithm. Simulation results show that the proposed method is valid for a wide range of optical properties and the related measurement can be simple and adaptable. Experimental demonstration was performed on a set of liquid phantoms in a wide range of absorption coefficients and reduced scattering coefficients and with CW measurements in different optode separations. The results show that, with the developed method, the optical properties calculated from the experimental data deviate form the "true value" by no more than 10%.
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Tangbing Guan, Tangbing Guan, Huijuan Zhao, Huijuan Zhao, Zhaoxia Wang, Zhaoxia Wang, Daoyin Yu, Daoyin Yu, } "Optical properties reconstruction of layered tissue and the experimental demonstration", Proc. SPIE 6436, Complex Dynamics and Fluctuations in Biomedical Photonics IV, 643611 (7 February 2007); doi: 10.1117/12.697035; https://doi.org/10.1117/12.697035

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