Detection and noninvasive diagnostics of breast cancer with 2-color laser optoacoustic imaging system

Sergey Ermilov; Alan Stein; Andre Conjusteau; Reda Gharieb; Ron Lacewell; Tom Miller; Scott Thompson; Pamela Otto; Barbara McCorvey; Tuenchit Khamapirad; Morton Leonard; Alexander Oraevsky

doi:10.1117/12.714039

15 February 2007 Detection and noninvasive diagnostics of breast cancer with 2-color laser optoacoustic imaging system

Sergey Ermilov, Alan Stein, Andre Conjusteau, Reda Gharieb, Ron Lacewell, Tom Miller, Scott Thompson, Pamela Otto, Barbara McCorvey, Tuenchit Khamapirad, Morton Leonard, Alexander Oraevsky

Author Affiliations +

Proceedings Volume 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 643703 (2007) https://doi.org/10.1117/12.714039
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

We have designed, fabricated and tested a new laser optoacoustic imaging system (LOIS-64/16) for quantitative optoacoustic tomography of breast cancer. The system was designed to create a single slice of an optoacoustic image of the breast with 64 ultrawide band acoustic transducers. Other 16 transducers on the back of the acoustic probe were used to reconstruct the light distribution inside the breast. The system resolution was at least 0.5 mm for high-aspect-ratio objects. Maximum system sensitivity was 4.8 mV/Pa and the RMS noise of 3.1 mV, which allowed imaging of small (less than 1 cm) tumors at depths over 3 cm. The directivity of the optoacoustic transducers used in LOIS-64/16 assured that the signal detection was better than 70% of the maximum for about 75% of the imaging slice and reduced quickly for signals coming from out of the imaging slice. Implemented signal processing allowed significant reduction of the low-frequency acoustic noise and localizing the small OA signals. The system was able to differentiate phantoms mimicking tumors and malformations visualized in clinics based on the contrast and morphology of their images obtained at 1064 nm and 757 nm.

Citation Download Citation

Sergey Ermilov, Alan Stein, Andre Conjusteau, Reda Gharieb, Ron Lacewell, Tom Miller, Scott Thompson, Pamela Otto, Barbara McCorvey, Tuenchit Khamapirad, Morton Leonard, and Alexander Oraevsky "Detection and noninvasive diagnostics of breast cancer with 2-color laser optoacoustic imaging system", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643703 (15 February 2007); https://doi.org/10.1117/12.714039

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available