13 February 2007 Measurement of blood perfusion using photoacoustic, ultrasound, and strain imaging
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Abstract
In many clinical and research applications including cancer diagnosis, tumor response to therapy, reconstructive surgery, monitoring of transplanted tissues and organs, and quantitative evaluation of angiogenesis, sequential and quantitative assessment of microcirculation in tissue is required. In this paper we present an imaging technique capable of spatial and temporal measurements of blood perfusion through microcirculation. To demonstrate the developed imaging technique, studies were conducted using phantoms with modeled small blood vessels of various diameters positioned at different depths. A change in the magnitude of the photoacoustic signal was observed during vessel constriction and subsequent displacement of optically absorbing liquid present in the vessels. The results of the study suggest that photoacoustic, ultrasound and strain imaging could be used to sequentially monitor and qualitatively assess blood perfusion through microcirculation.
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Srivalleesha Mallidi, Srivalleesha Mallidi, Andrei B. Karpiouk, Andrei B. Karpiouk, Salavat R Aglyamov, Salavat R Aglyamov, Shriram Sethuraman, Shriram Sethuraman, Stanislav Y. Emelianov, Stanislav Y. Emelianov, } "Measurement of blood perfusion using photoacoustic, ultrasound, and strain imaging", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643707 (13 February 2007); doi: 10.1117/12.701230; https://doi.org/10.1117/12.701230
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