Photoacoustic detection of circulating melanoma cells in vitro

Ryan M. Weight; Paul S. Dale; Gerardo Gutierrez-Juarez; Charles W. Caldwell; Allison B. Lisle; John A. Viator

doi:10.1117/12.698712

13 February 2007 Photoacoustic detection of circulating melanoma cells in vitro

Ryan M. Weight, Paul S. Dale, Gerardo Gutierrez-Juarez, Charles W. Caldwell, Allison B. Lisle, John A. Viator

Proceedings Volume 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 643708 (2007) https://doi.org/10.1117/12.698712
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

The prognostic value of exposing malignant melanoma poses an urgent need for an efficient, accurate screening method for metastatic cells. We propose a system for the detection of metastatic tumor cells based upon the thermo-elastic properties of melanoma. The method employs photoacoustic excitation coupled with a detection system capable of exposing cells within the circulatory system in vitro. Initial trials provided a threshold on the order of ten individual cells. Results imply the potential to assay simple blood draws for the presence of cancerous melanoma providing an unprecedented method for routine cancer screening.

Citation Download Citation

Ryan M. Weight, Paul S. Dale, Gerardo Gutierrez-Juarez, Charles W. Caldwell, Allison B. Lisle, and John A. Viator "Photoacoustic detection of circulating melanoma cells in vitro", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643708 (13 February 2007); https://doi.org/10.1117/12.698712

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