13 February 2007 Acoustic fingerprints of photoacoustic contrast agents for molecular imaging
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Protein nanospheres capable of frequency controlled oscillation in response to laser stimulation are presented as contrast agents for photoacoustic imaging. Incident laser energy absorbed by dye-labeled protein nanospheres causes thermoelastically generated sound production. Plotted A-line graphs reveal a distinctive morphology and greater than 2 orders of magnitude increase in signal amplitude subsequent to converting labeled proteins into nanospheres. Evidence of nonlinearity and enhancement of ultrasound backscatter indicate a potential use in contrast-enhanced harmonic imaging. Photoacoustic and ultrasound imaging of protein nanospheres in phantom vessels show enhanced contrast at low concentration and clear delineation of the phantom vessel wall.
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Michael A. McDonald, Michael A. McDonald, Ladislav Jankovic, Ladislav Jankovic, Khalid Shahzad, Khalid Shahzad, Michael Burcher, Michael Burcher, King C.P. Li, King C.P. Li, } "Acoustic fingerprints of photoacoustic contrast agents for molecular imaging", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64370L (13 February 2007); doi: 10.1117/12.702355; https://doi.org/10.1117/12.702355

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