13 February 2007 Photoacoustic imaging of tumor vascularization on nude mice
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Abstract
Photoacoustic imaging (PAI) has been shown to have higher spatial resolution and optical contrast than conventional ultrasound imaging due to the high contrast absorption of blood on green and near infrared (NIR) light. We conducted in-vivo PAI of tumor blood vessels - monitoring 3-24 days development of tumor after the implant of the tumor cells on the back of nude mice. We observed that the PAI signals increased with the blood vessel developments and the growth of the tumor. This study shows that PAI is suitable for monitoring of the development of blood vessels near the superficial tumors. These results demonstrate the usefulness of the PAI for tumor angiogenesis monitoring in small animals.
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Bson Chiu, Shu-Wei Huang, Huihua Kenny Chiang, "Photoacoustic imaging of tumor vascularization on nude mice", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64370T (13 February 2007); doi: 10.1117/12.700255; https://doi.org/10.1117/12.700255
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