13 February 2007 Co-registered 3-D ultrasound and photoacoustic imaging using a 1.75D 1280-channel ultrasound system
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Photoacoustic imaging is a promising non-invasive imaging technology due to its ability to combine the enhanced contrast of optical absorption with the spatial resolution of acoustic imaging. Co-registered three-dimensional (3-D) ultrasound and photoacoustic imaging takes advantage of both modalities to allow visualization of tissue structures within a volume using simultaneous structural and functional information. 1.75D acoustic arrays are well-suited for this application due to their ability to scan in 3-D volumes rapidly and accurately while maintaining a reasonable system complexity and cost. We have designed, fabricated, and tested a 1.75D 1280-ch ultrasound system for co-registered 3-D ultrasound and photoacoustic imaging. The system features a 1.75D 1280-channel ultrasound array with a center frequency of 5MHz and 80% bandwidth. The electronics includes 1280 high-voltage pulsers, 40 32-to-1 multiplexers, amplification circuitry, and a 40-channel data acquisition circuit. The system is able to drive the entire array simultaneously, and each array element independently, to scan a 3-D volume within +/- 40 degrees in azimuth direction and +/- 10 degrees in elevation respectively. System performance including axial and lateral resolution has been characterized and compared with simulations. Co-registered 3-D ultrasound and photoacoustic imaging has been successfully performed on phantoms with different geometries and contrast.
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Puyun Guo, Puyun Guo, John Gamelin, John Gamelin, Shikui Yan, Shikui Yan, Andres Aguirre, Andres Aguirre, Quing Zhu, Quing Zhu, } "Co-registered 3-D ultrasound and photoacoustic imaging using a 1.75D 1280-channel ultrasound system", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643713 (13 February 2007); doi: 10.1117/12.706702; https://doi.org/10.1117/12.706702

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