13 February 2007 Ultrasound-tagged light assessment of osteoporosis
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Last researches on Osteoporosis disease show's that the correlation between BMD information that come from DXA, and the fractual risk are not enough correlated. For this reason, new techniques that could be more sensitive and give different information's on the bone are being looking for. The key for success is to find a technique that could be detected changes in the micro-structure inside the trabecular bone, and supply more information on this structure. We have shown that pulse ultrasound light tomography could work in well reflection configuration and on living tissue to measure locally the "reduce scattering coefficient" inside the body. This technique could work deep inside the body (few cm) and could supply very good resolution. In the beginning on this research we show clinical results that justified planning more accurate and larger clinical study. The system suffers from mechanical and body interface problems that only very skill and professional physician could get a good results. This system also suffers from low signal to noise ratio, and irrevocable data on the same people. In this lecture we will present an upgrade and improved system. The mechanical and body interface changes will present and discusses. A good repeated data will be presented on phantoms and on peoples. Finally, large clinical data that operated in clinical technician on 60 Ultra distal bone peoples will present in compare to DXA data that was measure on the same peoples on the same place.
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A. Lev, E. Rubanov, B. Sfez, Y. Tsiplevich, J. Foldes, "Ultrasound-tagged light assessment of osteoporosis", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64371I (13 February 2007); doi: 10.1117/12.694340; https://doi.org/10.1117/12.694340

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