19 February 2007 Single fiber optical tweezers for manipulation of microscopic objects
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Abstract
Trapping of microscopic objects using fiber optical traps is gaining considerable interest since it has the potential to manipulate objects inside turbid medium such as tissue, thus removing the limitation of short working distance of the conventional optical tweezers based on high numerical aperture microscope objective. Here, we show that scattering force of an output beam from a single fiber can be reduced as compared to the axial gradient force when an axicon is built on the tip of the fiber, thus enabling single beam fiber-optic tweezers. Trapping of wide range of objects in size range of few hundreds of nanometers to tens of micrometers could thus be achieved. This fiber optic tweezers could be easily maneuvered in all three directions by moving the mechanical manipulator holding the axicon tip fiber. Further, chain of upto 40 particles could be trapped along the axial direction, which can be attributed as longitudinal optical binding where each trapped object acts as lens to trap subsequent object near its focal point. Apart from miniaturization capability, axicon tipped optical fiber can be used in multi-functional mode for cellular manipulation, as well as for two-photon fluorescence excitation for biomedical diagnosis.
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Samarendra Mohanty, Samarendra Mohanty, Khyati Mohanty, Khyati Mohanty, } "Single fiber optical tweezers for manipulation of microscopic objects", Proc. SPIE 6441, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, 644116 (19 February 2007); doi: 10.1117/12.707917; https://doi.org/10.1117/12.707917
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