19 February 2007 Iron oxide nanoparticles as drug delivery agents in MIA PaCa-2 pancreatic cells
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Abstract
Oleic acid (OA)-Pluronic-coated iron oxide nanoparticles were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and Atomic Force Microscopy (AFM). FT-IR confirmed the bonding of oleic acid and Pluronic (surfactant) to the nanoparticles. AFM measurements on these nanoparticles indicated a root mean square (RMS) roughness, a measure of nanoparticle size of (50 ± 20) nm. The efficiency of these functionalized nanoparticles was investigated by loading with 5-Fluorouracil (5-FU) in aqueous solution. AFM measurements were used to characterize modified iron oxide nanoparticles and pancreatic MIA PaCa-2 cells, including size distribution, stability and cellular uptake. Nanoparticles were added to MIA PaCa-2 cells and assayed for their cytotoxic effects after 24 and 48 hours. The outcome of this study demonstrated the effectiveness of oleic acid (OA)-Pluronic-coated iron oxide nanoparticles as a non-toxic drug delivery agent for pancreatic cancer.
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Christopher Perry, Christopher Perry, Alexandrine Randriamahefa, Alexandrine Randriamahefa, Carl Lokko, Carl Lokko, Whitney Evans, Whitney Evans, Julian Watkins, Julian Watkins, Holly Carrell, Holly Carrell, Natalie King, Natalie King, Darayas Patel, Darayas Patel, } "Iron oxide nanoparticles as drug delivery agents in MIA PaCa-2 pancreatic cells", Proc. SPIE 6441, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, 64411T (19 February 2007); doi: 10.1117/12.701754; https://doi.org/10.1117/12.701754
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