In vivo multiphoton tomography of skin during wound healing and scar formation

Iris Riemann; Alexander Ehlers; Ronan LeHarzic; Sven Martin; Annette Reif; Karsten König

doi:10.1117/12.702407

10 February 2007 In vivo multiphoton tomography of skin during wound healing and scar formation

Iris Riemann, Alexander Ehlers, Ronan LeHarzic, Sven Martin, Annette Reif, Karsten König

Proceedings Volume 6442, Multiphoton Microscopy in the Biomedical Sciences VII; 644226 (2007) https://doi.org/10.1117/12.702407
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Multiphoton tomography based on femtosecond laser NIR (near infrared) pulses was used to perform non-invasive optical sectioning of skin with high spatial and intracellular resolution. Scar formation due to formation of collagen fibers is an important aspect during wound healing processes in skin and tissues and was monitored in vivo using the system DermaInspect. Multiphoton tomography was performed of a dermal wound after nevi extraction. The healing process and the aggregation of collagen fibers could be long term monitored due to the autofluorescence of endogenous fluorophores and SHG of collagen. The system DermaInspect might become a high resolution diagnostic tool for dermatological diagnostics and monitoring therapeutic effects.

Citation Download Citation

Iris Riemann, Alexander Ehlers, Ronan LeHarzic, Sven Martin, Annette Reif, and Karsten König "In vivo multiphoton tomography of skin during wound healing and scar formation", Proc. SPIE 6442, Multiphoton Microscopy in the Biomedical Sciences VII, 644226 (10 February 2007); https://doi.org/10.1117/12.702407

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