10 February 2007 Real time on-line intracavity detection of chemicals in solution
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Abstract
We have investigated the application of narrow-band intracavity spectroscopy for high throughput characterization and detection of reaction products in-situ. An external cavity diode laser (ECDL), tunable from 810-890 nm, is used to measure varying concentrations of a range of compounds in solution. A linear calibration curve for parts per billion (ppb) concentrations corresponding to 17 nM has been achieved, levels not detectable with UV/VIS spectrometers. By replacing the grating with a high reflective mirror, parts per trillion (ppt) concentration detection was also achieved corresponding to 340 pM. We believe that this technique provides a method for fast and safe measurements of reactions in real time and has potential applications in the pharmaceutical and chemical industry as well as for integrated bio-diagnostics lab-on-a-chip devices.
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Untzizu Elejalde, John M. Girkin, "Real time on-line intracavity detection of chemicals in solution", Proc. SPIE 6444, Ultrasensitive and Single-Molecule Detection Technologies II, 644407 (10 February 2007); doi: 10.1117/12.696558; https://doi.org/10.1117/12.696558
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