15 February 2007 Optical glucose sensing in biotissue phantom by diffuse reflectance technique
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The feasibility of spatial resolved reflectometry (SRR) and time-of-flight (TOF) techniques application at the wavelength of 820 nm for the detection of changes in optical properties of multilayer scattering medium was considered. The model SRR and TOF signals from a 3-layer biotissue phantom mimicking two skin layers and a blood layer between them were obtained by using Monte Carlo method. It was assumed that changes in the glucose level induce changes only in the blood layer and the deeper skin layer. The scattering maps were obtained in order to analyze the trajectories of the photons contributing to the signals. Different characteristics of the TOF signal were analyzed. Relative changes of the signals induced by the glucose level variations were analyzed for different source-detector separations. It was shown that the maximal relative change of the signal for both techniques of about 7% corresponding to the glucose concentration change from 0 to 500 mg/dl takes place for source-detector separations in the range from 0.3 to 0.5 mm depending on the model parameters.
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Mikhail Yu. Kirillin, Mikhail Yu. Kirillin, Alexander V. Bykov, Alexander V. Bykov, Alexander V. Priezzhev, Alexander V. Priezzhev, Risto Myllyla, Risto Myllyla, "Optical glucose sensing in biotissue phantom by diffuse reflectance technique", Proc. SPIE 6445, Optical Diagnostics and Sensing VII, 64450U (15 February 2007); doi: 10.1117/12.706109; https://doi.org/10.1117/12.706109

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