14 February 2007 Molecular imaging of photodynamic therapy efficacy
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Abstract
Recent advances in light sources, detectors and other optical imaging technologies coupled with the development of novel optical contrast agents have enabled real-time, high resolution, in vivo monitoring of molecular targets. Noninvasive monitoring of molecular targets can help optimize photodynamic therapy (PDT) by providing the capabilities to monitor the efficacy of treatment. Our lab has developed optical imaging technologies to investigate a wide range of molecular, physiological and morphological responses to photodynamic therapy (PDT). With the idea that drug delivery to the different compartments in the tumor is an important determinant of the treatment effect, we studied drug delivery in vitro and in vivo using optical imaging tools. A molecular specific contrast agent that targets the vascular endothelial growth factor (VEGF) was developed to monitor the changes in the protein expression following PDT. We also studied the PDT-induced physiological changes in vascular permeability and metastasis with in vivo imaging.
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Sung K. Chang, Sung K. Chang, Nicolas Solban, Nicolas Solban, Imran Rizvi, Imran Rizvi, Divya Errabelli, Divya Errabelli, Tayyaba Hasan, Tayyaba Hasan, } "Molecular imaging of photodynamic therapy efficacy", Proc. SPIE 6449, Genetically Engineered and Optical Probes for Biomedical Applications IV, 644902 (14 February 2007); doi: 10.1117/12.714889; https://doi.org/10.1117/12.714889
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