13 February 2007 Oligonucleotide functionalized Fabry-Perot interferometric probe for DNA sequence detection
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Abstract
This paper presents a novel fiber optic Fabry-Perot (FP) structure for direct detection of deoxyribonucleic acid (DNA) sequences. The capture DNA is immobilized onto the surface of a silica optical fiber tip by means of the layer-by-layer electrostatic self-assembly (L-b-L ESA) technique. With the FP cavity inside the fiber, the change in optical path length difference (OPD) caused by the immobilization and hybridization can be demodulated. Experimental results demonstrate short (~5 min) response time. In addition, the sensor fabrication is simple and low cost. The signal is stable with high visibility.
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Xingwei Wang, Juncheng Xu, Zhuang Wang, Kristie L. Cooper, Anbo Wang, Chengdong Cao, "Oligonucleotide functionalized Fabry-Perot interferometric probe for DNA sequence detection", Proc. SPIE 6449, Genetically Engineered and Optical Probes for Biomedical Applications IV, 64490G (13 February 2007); doi: 10.1117/12.697431; https://doi.org/10.1117/12.697431
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