Receptor-free nanomechanical sensors

Larry R. Senesac; Dechang Yi; Thomas Thundat

doi:10.1117/12.708237

19 January 2007 Receptor-free nanomechanical sensors

Larry R. Senesac, Dechang Yi, Thomas Thundat

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Proceedings Volume 6463, Reliability, Packaging, Testing, and Characterization of MEMS/MOEMS VI; 646302 (2007) https://doi.org/10.1117/12.708237
Event: MOEMS-MEMS 2007 Micro and Nanofabrication, 2007, San Jose, California, United States

Abstract

Nanomechanical response of molecular adsorption has been demonstrated as the basis for a number of extremely sensitive sensors. Molecular adsorption on microcantilevers results in nanomechanical motion due to adsorption-induced surface stress variation. Chemical selectivity in nanomechanical sensors is achieved by immobilizing receptors on the cantilever surface. Although receptor-based detection has high selectivity for biomolecular detection, it fails when applied to small molecule detection. Nanomechanics, however, offer new possibilities for achieving chemical selectivity that do not use any receptors. For example, small thermal mass or high temperature sensitivity of a cantilever beam could be used for detecting molecular adsorption using photothermal effects and physical property variation due to temperature. Here we describe two such techniques for achieving chemical selectivity without using any receptor molecules.

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Larry R. Senesac, Dechang Yi, and Thomas Thundat "Receptor-free nanomechanical sensors", Proc. SPIE 6463, Reliability, Packaging, Testing, and Characterization of MEMS/MOEMS VI, 646302 (19 January 2007); https://doi.org/10.1117/12.708237

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KEYWORDS

Sensors

Molecules

Receptors

Adsorption

Absorption

Resistance

Chlorine

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