Using a CD-like microfluidic platform for uniform calcium alginate drug carrier generation

Ming-Kai Liu; Keng-Shiang Huang; Jia-Yaw Chang; Chun-Han Wu; Yu-Cheng Lin

doi:10.1117/12.705413

22 January 2007 Using a CD-like microfluidic platform for uniform calcium alginate drug carrier generation

Ming-Kai Liu, Keng-Shiang Huang, Jia-Yaw Chang, Chun-Han Wu, Yu-Cheng Lin

Proceedings Volume 6465, Microfluidics, BioMEMS, and Medical Microsystems V; 646508 (2007) https://doi.org/10.1117/12.705413
Event: MOEMS-MEMS 2007 Micro and Nanofabrication, 2007, San Jose, California, United States

Abstract

In this paper the manipulation of monodisperse Ca-alginate microparticles using a polymer-based CD-like microfluidic platform and a reaction of external gelation is presented. Our strategy was based on associating the rapid injection molding process for cross-junction microchannel with the sheath focusing effect to form uniform water-in-oil (w/o) emulsions. These fine emulsions, consisting of 1.5% w/v Na-alginate, were then dripped into an oil solution containing 20% w/v calcium chloride (CaCl₂) to accomplish Ca-alginate microspheres in an efficient manner. We have demonstrated that one can control the size of Ca-alginate microparticles from 20 µm to 50 µm in diameter (with a variation less than 10%) by altering the relative sheath/sample flow rate ratio. Experimental data showed that for a given fixed dispersed phase flow (sample flow), the emulsion size decreased as the average velocity of the continuous phase (oil flow) increased. The proposed CD-like microfluidic platform is capable of generating relatively uniform microdroplets and has the advantages of active control of droplet diameter, simple and low cost process, and high throughput.

Citation Download Citation

Ming-Kai Liu, Keng-Shiang Huang, Jia-Yaw Chang, Chun-Han Wu, and Yu-Cheng Lin "Using a CD-like microfluidic platform for uniform calcium alginate drug carrier generation", Proc. SPIE 6465, Microfluidics, BioMEMS, and Medical Microsystems V, 646508 (22 January 2007); https://doi.org/10.1117/12.705413

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