Simultaneous surface and volume registration using harmonic maps

Anand A. Joshi; David W. Shattuck; Paul M. Thompson; Richard M. Leahy

doi:10.1117/12.718137

28 February 2007 Simultaneous surface and volumetric registration using harmonic maps

Anand A. Joshi, David W. Shattuck, Paul M. Thompson, Richard M. Leahy

Proceedings Volume 6498, Computational Imaging V; 649816 (2007) https://doi.org/10.1117/12.718137
Event: Electronic Imaging 2007, 2007, San Jose, CA, United States

Abstract

Inter-subject analysis of anatomical and functional brain imaging data requires the images to be registered to a common coordinate system in which anatomical features are aligned. Intensity-based volume registration methods can align subcortical structures well, but the variability in sulcal folding patterns typically results in misalignment of the cortical surface. Conversely, surface-based registration using sulcal features can produce excellent cortical alignment but the mapping between brains is restricted to the cortical surface. Here we describe a method for volumetric registration that also produces a one-to-one point correspondence between cortical surfaces. This is achieved by first parameterizing and aligning the cortical surfaces. We then use a constrained harmonic mapping to define a volumetric correspondence between brains. Finally, the correspondence is refined using an intensity-based warp. We evaluate the performance of our proposed method in terms of the inter-subject alignment of expert-labeled sub-cortical structures after registration.

Citation Download Citation

Anand A. Joshi, David W. Shattuck, Paul M. Thompson, and Richard M. Leahy "Simultaneous surface and volumetric registration using harmonic maps", Proc. SPIE 6498, Computational Imaging V, 649816 (28 February 2007); https://doi.org/10.1117/12.718137

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