17 March 2007 Dual energy contrast enhanced breast imaging optimization using contrast to noise ratio
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The properties of dual energy contrast enhanced breast imaging have been analyzed by imaging a 4 cm breast equivalent phantom consisting of adipose and glandular equivalent plastics. This phantom had superimposed another thin plastic which incorporated a 2 mm deep cylinder filled with iodinated contrast media. The iodine projected thicknesses used for this study was 3 mg/cm2. Low and high energy spectra that straddle the iodine K-edge were used. Critical parameters such as the energy spectra and exposure are discussed, along with post processing by means of nonlinear energy dependent function. The dual energy image was evaluated using the relative contrast to noise ratio of a 2.5 mm x 2.5 mm region of the image at the different iodine concentrations incorporating different breast composition with respect to the noniodinated areas. Optimum results were achieved when the low and high-energy images were used in such a way that relative contrast to noise ratio of the iodine with respect to the background tissue was maximum. A figure of merit suggests that higher noise levels can be tolerated at the benefit of lower exposure. Contrast media kinetics of a phantom incorporating a water flow of 20.4 ml/min through the plastic cylinder suggests that time domain imaging could be performed with this approach. The results suggest that optimization of dual energy contrast enhanced mammography has the potential to lead to the development of perfusion digital mammography.
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C. D. Arvanitis, C. D. Arvanitis, G. Royle, G. Royle, R. Speller, R. Speller, } "Dual energy contrast enhanced breast imaging optimization using contrast to noise ratio", Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 65102Y (17 March 2007); doi: 10.1117/12.713167; https://doi.org/10.1117/12.713167

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