14 March 2007 Mean absorbed dose to mouse in micro-CT imaging with an ultrafast laser-based x-ray source
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We have investigated theoretically the mean absorbed dose to the mouse in our newly constructed, in-line holography, x-ray phase-contrast, in-vivo, micro-CT system with an ultrafast laser-based x-ray (ULX) source. We assumed that the effective mouse diameter was 30 mm and the x-ray detector required minimum 30 μGy per frame to produce high quality images. The following laser target-filter combinations were considered: Ag-Ag, Mo-Mo, Sn- Sn. In addition, we considered narrow-pass multilayer x-ray mirrors. The corresponding ULX spectra were obtained using a CZT solid-state spectrometer. The approach used for dose computation was similar to human dose estimation. The mouse was modeled as a tissue-equivalent cylinder located at the isocenter with diameter 30 mm and density 1g/cm3. A layer of dermis (skin and fur) with 1 mm thickness was also modeled. Imparted energy per volume was estimated for 1 keV wide x-ray energy intervals in the 6-100 keV range. Monte Carlo simulations were performed using the SIERRA code previously validated using 30 mm diameter PMMA phantom. The results obtained indicate that: a) the mean absorbed dose for ULX is less than or equal to that from a W-anode micro-CT tube operating at 30-40 kVp with 0.5 or 1.0 mm Al; b) for filter thickness above 100 μm, Sn-Sn results in the highest dose, followed by Ag-Ag and Mo-Mo; c) the multilayer x-ray mirror with FWHM ≤ 10 keV produces significantly lower dose than metallic foil filters. We conclude that ULX can provide better dose utilization than a microfocal x-ray tube for in vivo microtomography applications.
© (2007) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Andrzej Krol, Andrzej Krol, Hongwei Ye, Hongwei Ye, Russell Kincaid, Russell Kincaid, John Boone, John Boone, Marina Servol, Marina Servol, Jean-Claude Kieffer, Jean-Claude Kieffer, Yakov Nesterets, Yakov Nesterets, Tim Gureyev, Tim Gureyev, Andrew Stevenson, Andrew Stevenson, Steve Wilkins, Steve Wilkins, Edward Lipson, Edward Lipson, Remy Toth, Remy Toth, Andrew Pogany, Andrew Pogany, Ioana Coman, Ioana Coman, } "Mean absorbed dose to mouse in micro-CT imaging with an ultrafast laser-based x-ray source", Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 65103P (14 March 2007); doi: 10.1117/12.713827; https://doi.org/10.1117/12.713827


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