29 March 2007 Modulated imaging: a novel method for quantifying tissue chromophores in evolving cerebral ischemia
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Abstract
The authors report the results of utilizing spatially-modulated near infrared light using Modulated Imaging (MI) technology in imaging cerebral ischemia. MI images of the left parietal somatosensory cortex were obtained post-occlusion and up to three hours following middle cerebral artery occlusion. Tissue chromophore maps were obtained to demonstrate spatiotemporal changes in the distribution of oxy, deoxy, total hemoglobin, and oxygen saturation. MI recorded a decrease in oxyhemoglobin concentration and tissue oxygen saturation and increase in tissue deoxyhemoglobin concentration following occlusion. Optical intrinsic signal was used to detect functional activation of the somatosensory barrel cortex to whisker stimulation. This activation was completely lost following occlusion. Imaging findings in a transient ischemic attack using photothrombosis is also demonstrated.
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David Abookasis, Marlon S. Mathews, Chistopher Lay, Ron D. Frostig, Bruce J. Tromberg, "Modulated imaging: a novel method for quantifying tissue chromophores in evolving cerebral ischemia", Proc. SPIE 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, 65110A (29 March 2007); doi: 10.1117/12.713470; https://doi.org/10.1117/12.713470
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