Craniofacial statistical deformation models of wild-type mice and Crouzon mice

Hildur Ólafsdóttir; Tron A. Darvann; Bjarne K. Ersbøll; Nuno V. Hermann; Estanislao Oubel; Rasmus Larsen; Alejandro F. Frangi; Per Larsen; Chad A. Perlyn; Gillian M. Morriss-Kay; Sven Kreiborg

doi:10.1117/12.697406

26 March 2007 Craniofacial statistical deformation models of wild-type mice and Crouzon mice

Hildur Ólafsdóttir, Tron A. Darvann, Bjarne K. Ersbøll, Nuno V. Hermann, Estanislao Oubel, Rasmus Larsen, Alejandro F. Frangi, Per Larsen, Chad A. Perlyn, Gillian M. Morriss-Kay, Sven Kreiborg

Author Affiliations +

Proceedings Volume 6512, Medical Imaging 2007: Image Processing; 65121C (2007) https://doi.org/10.1117/12.697406
Event: Medical Imaging, 2007, San Diego, CA, United States

Abstract

Crouzon syndrome is characterised by premature fusion of cranial sutures and synchondroses leading to craniofacial growth disturbances. The gene causing the syndrome was discovered approximately a decade ago and recently the first mouse model of the syndrome was generated. In this study, a set of Micro CT scans of the heads of wild-type (normal) mice and Crouzon mice were investigated. Statistical deformation models were built to assess the anatomical differences between the groups, as well as the within-group anatomical variation. Following the approach by Rueckert et al. we built an atlas using B-spline-based nonrigid registration and subsequently, the atlas was nonrigidly registered to the cases being modelled. The parameters of these registrations were then used as input to a PCA. Using different sets of registration parameters, different models were constructed to describe (i) the difference between the two groups in anatomical variation and (ii) the within-group variation. These models confirmed many known traits in the wild-type and Crouzon mouse craniofacial anatomy. However, they also showed some new traits.

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Hildur Ólafsdóttir, Tron A. Darvann, Bjarne K. Ersbøll, Nuno V. Hermann, Estanislao Oubel, Rasmus Larsen, Alejandro F. Frangi, Per Larsen, Chad A. Perlyn, Gillian M. Morriss-Kay, and Sven Kreiborg "Craniofacial statistical deformation models of wild-type mice and Crouzon mice", Proc. SPIE 6512, Medical Imaging 2007: Image Processing, 65121C (26 March 2007); https://doi.org/10.1117/12.697406

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