Small errors in the alignment between CT Attenuation Correction (CTAC) images and Positron Emission Tomography
(PET) acquisitions can result in significant changes in PET attenuation corrected images. Misalignment due to
respiratory or cardiac motion can produce mismatch between the PET and CTAC acquisitions. This contributes to
artifactual hypoperfusion defects that are interpretable as myocardial ischemia or infarct. Correction for the
misalignment between the PET and CTAC images can eliminate these false positive artifacts. Two methods for
correcting for this respiratory and cardiac misalignment were compared. The first was an existing procedure, the
manual-shift method, using point-to-point, in-plane, two-dimensional (2D) measurements of the shifts in axial, sagittal,
and coronal planes. A new PET image reconstruction using the corrected attenuation map shifted by the 2D
measurements was then performed. In the second method, the Interactive ACQC method, visual alignment was
performed between the left ventricle boundaries on fused images and automated calculation of necessary rigid three-dimensional
(3D) alignment parameters was performed. A new PET image reconstruction was then performed with an
attenuation map shifted by the prescribed alignment parameters. The two methods were compared for accuracy and
workflow efficiency using five cardiac PET/CT cases, scanned on GE Discovery VCT and Discovery ST systems.
Alignment measurements using the visual alignment process (the interactive ACQC method) improved productivity by
over five minutes, on average. The results show that the interactive ACQC procedure yields similar results to those of
the point-to-point procedure while providing improved workflow for cardiac PET attenuation correction quality control.