Nanowire integrated microelectrode arrays for lab-on-a-chip applications

Jose K. Abraham; Hargsoon Yoon; Vijay Varadan; Ritesh Chintakuntla

doi:10.1117/12.717662

11 April 2007 Nanowire integrated microelectrode arrays for lab-on-a-chip applications

Jose K. Abraham, Hargsoon Yoon, Vijay Varadan, Ritesh Chintakuntla

Proceedings Volume 6528, Nanosensors, Microsensors, and Biosensors and Systems 2007; 65280O (2007) https://doi.org/10.1117/12.717662
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2007, San Diego, California, United States

Abstract

The monitoring of biological signals generated during nerve excitation and cell-to-cell communication are important for design and development of novel materials and methods for laboratory analysis. In-vitro biological applications such as drug screening and cell separation also require cell-based biosensors. The sensing technology is based on the optical or electrical read-out from the lab-on-a-chip. The electrophysiological activity of certain cells such as neurons and cardiac cells are monitored using planar microelectrode arrays integrated with microfluidic devices. One of the main issues of the current microelectrode array design is the difficulty in selective integration and the size dependency of its impedances along with a large amount of noise in the circuit due to this mismatch. It is quite evident that nanotechnology can solve these problems and an efficient electrical interconnection is possible using nanodevices. This paper presents the design and development of planar microelectrode arrays integrated with vertically aligned nanowires for lab-on-a-chip device applications. The higher surface area densities of such nanowire integrated microelectrode arrays show promising results in impedance control for the integration of lab-on-a-chip devices. We have fabricated microelectrode arrays on silicon and flexible polymer substrates and vertically aligned nanowires were fabricated onto it using template method. High degree of specific growth is obtained by controlling the nanowire growth parameters.

Citation Download Citation

Jose K. Abraham, Hargsoon Yoon, Vijay Varadan, and Ritesh Chintakuntla "Nanowire integrated microelectrode arrays for lab-on-a-chip applications", Proc. SPIE 6528, Nanosensors, Microsensors, and Biosensors and Systems 2007, 65280O (11 April 2007); https://doi.org/10.1117/12.717662

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KEYWORDS

Nanowires

Lab on a chip

Electrodes

Biological research

Metals

Photoresist materials

Silicon

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