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11 April 2007 Piezoelectric 3D nanostructures for developing point-of-care biosensors
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Minimal invasive determinations of various physiological parameters are more and more demanding for medical applications. Many techniques have been evolved in nanotechnology using one dimensional nanostructures to aid the analytical tools for chemical and biosensing, disease diagnosis and treatment. Nanowire sensing probes have potential applications not only in electronics and optoelectroncs industry, but have tremendous potential in evaluating minute changes in cellular level, particularly for designing various sensing and diagnosis tools. A review of the development of vertically aligned piezoelecronic nanowire arrays and 3-D nanostructures for the design of biomedical sensors for pointof- care applications are presented in this paper. The deflections of a vertically aligned piezoelectric nanowire arrays can be used for the generation of voltages and can be used for the measurement of various parameters such as pressure, temperature, blood flow and glucose detection. Vertically aligned ZnO nanostructure has the advantages of generating piezoelectric voltages that can be coupled with MEMS sensors for the development of point-of-care biosensors.
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Jose K. Abraham, Sridhar Dubaka, Vijay K. Varadan, Huajun Zhou, Tierui Zhang, and Z. Ryan Tian "Piezoelectric 3D nanostructures for developing point-of-care biosensors", Proc. SPIE 6528, Nanosensors, Microsensors, and Biosensors and Systems 2007, 65280V (11 April 2007);

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