1 May 2007 Absorption spectrum characteristic of chorophyll derivatives photosensitizer CPD3
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Proceedings Volume 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine; 653425 (2007); doi: 10.1117/12.741634
Event: Fifth International Conference on Photonics and Imaging in Biology and Medicine, 2006, Wuhan, China
Abstract
Absorption spectrum of CPD3 is determined. There are two absorption bands all in absorption spectrum, the maximal absorption of band B is at 395nm in 0.9% NaCl solution and TE buffer solution, the band Q is locating at 677nm and 651nm respectively in solvents above. The order of magnitude of extinction coefficient is 104 in both solvents. the absorption peak of CPD3-DNA mix solution have 6nm and 23nm red shift for band B and band Q respectively compared with pure CPD3 in 0.9% NaCl solution, this indicates that interaction between photosensitizer and DNA occurring. Time series data of absorption for CPD3-DNA mix solution supports the interaction viewpoint further, and the full action time is about 90mins. The type of interaction needs a further investigating. Stronger absorption in red region and the interaction with DNA suggests that CPD3 will have a bright future in photodynamic therapy.
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Fenghua Xiang, Hui Liu, Youshan Lu, Ping Chen, Guoqing Tang, "Absorption spectrum characteristic of chorophyll derivatives photosensitizer CPD3", Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 653425 (1 May 2007); doi: 10.1117/12.741634; https://doi.org/10.1117/12.741634
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KEYWORDS
Absorption

Photodynamic therapy

Mass attenuation coefficient

Cancer

Chlorine

Luminescence

Molecules

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