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1 May 2007 Changes in capillary filling do not influence inspiratory-induced vasoconstrictive episodes
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Deep inspiration leads to sympathetically mediated vasoconstriction at the fingertip. This so-called inspiratory gasp response (IGR) is usually assessed by laser Doppler fluxmetry (LDF) and provides interesting information on the activity of the sympathetic nervous system. In this study we investigated if simple maneuvers which affect microcirculation have an effect on the IGR. For this we detected IGR with LDF in rest, after elevation of the arm to lower capillary filling, after venous congestion to increase capillary filling, and after heating up in warm water to induce vasodilation. Capillary filling was monitored with the Erlangen Microlightguide Spectrophotometer (EMPHO) by determination of the relative hemoglobin concentration. We found that IGR was not affected by microcirculatory starting conditions. Therefore, we conclude that diagnostic results of the IGR are not influenced by different capillary filling levels.
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Robert Rauh M.D., Elke Ochsmann, Manfred Kessler, and Michael Mueck-Weymann "Changes in capillary filling do not influence inspiratory-induced vasoconstrictive episodes", Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65350M (1 May 2007);

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