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26 April 2007 Monitor glucose induced changes in optical properties of rat skin in vitro
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Optical clearing technique of tissue most goes to qualitative analysis, it is more important to get the quantitative optical properties of tissue. A self-developed local measuring system had been used to monitor the dynamics of optical properties of rat skin under 30mins treatment with 40% glucose, and then 30 min recovery with saline. The thickness of native, and the end of two different administration stages were measured. The results show that, in 30 minutes' treatment of 40% glucose, tissue optical properties decreased. This change was very big in the first minute and reached a plateau after 25 minutes. The absorption coefficient, scattering coefficient and the sample thickness reduced to 88.6%, 71%, 85% of the original value, respectively. It may be that the glucose solution induced a dehydration process of skin. After the saline treatment, the three parameters of the tissue recovered to 96%, 94%, 90% of the original value, respectively. This result proved that the 40% glucose administration stage on the tissue properties is reversible.
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Dan Zhu, Wei Lu, Qin Li, Hui Gong, and Qingming Luo "Monitor glucose induced changes in optical properties of rat skin in vitro", Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65350P (26 April 2007);

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