26 April 2007 Hemispherical imaging of skin with polarized light
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Polarized light imaging has been used in the past for skin-cancer edge detection from skin lesions. In the standard imaging modality, the source, detector, and sample are usually aligned in the same plane, and the effect of the air-skin boundary is minimized using a glass slide with an index matching fluid. In this study, we investigate polarized light imaging of skin surfaces using a novel instrument that enables out-of-plane illumination. Stokes vector images are acquired for any one of sixteen different illumination directions and used to study the effect of skin roughness as well as surface and subsurface scattering. We show that the effect of skin roughness can be minimized or enhanced, depending upon the incident direction and polarization. In the former case, the need for a glass slide with an index matching fluid can be reduced. In the latter, surface topography can be more clearly discerned.
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Jessica C. Ramella-Roman, Bruno Boulbry, Thomas A. Germer, "Hemispherical imaging of skin with polarized light", Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65350U (26 April 2007); doi: 10.1117/12.740962; https://doi.org/10.1117/12.740962

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