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26 April 2007 Stratum corneum: a barrier of skin resistants light
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Abstract
Benzisothiazdone, a kind of safe and effective ketone containing heterocycle, was introduced as an enhancer to investigate the effect on optical clearing of the piglet skin with and without stratum corneum in vitro. The skin samples were treated with different agents, such as, pure polyethyleneglycol 400, mixed solution (benzisothiazdone combining with polyethyleneglycol 400) and isotonic saline. The total transmittance of samples was monitored by a single integrating sphere system. The results show that the saline does not affect the rate of optical clearing obviously. For the sample with stratum corneum, single optical clearing agent such as PEG400 penetrates slowly because of the barrier function of SC. The stratum corneum makes the effect of optical clearing on the sample inconspicuous. In contrast, the mixed solution can damage the barrier function of SC to some extent. For the sample without stratum corneum, an obvious increase in the rate of optical clearing is in the single PEG400 administration stage, this effect will be more remarkable if the Benzisothiazdone was used as an enhancer. We can conclude that SC can prevent skin from effecting of single OCA, but the barrier will become weaker if right immersion agent is adopted as the enhancer.
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Dan Zhu, Yating Hu, Zongzhen Mao, Ying Zheng, Wei Lu, and Qingming Luo "Stratum corneum: a barrier of skin resistants light", Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 653510 (26 April 2007); https://doi.org/10.1117/12.740971
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