20 June 2007 Diagnostic potentialities of plasmon-resonant nanoparticles as contrast agents for the diffuse back scattering spectroscopy of biotissues
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Abstract
The study is aimed at evaluation of diagnostic potential of plasmon-resonant nanoparticles as contrast agents for various techniques based on backward diffuse light scattering from biotissues. We consider the theoretical spectra of diffuse backscattering from a plane layer of gold nanospheres embedded into a plane layer of scattering dielectric spheres that mimic a strongly scattering sample of a biotissue. It is shown that the backscattering spectra contain information about 35-nm gold spheres provided the location depth is less than 600 mkm. The simulated color characteristics resemble the measured characteristics of a rat skin. The measured diffuse reflection spectra of 35-nm gold colloid are close to the spectra of 70/15-nm silica/gold nanoshells although the plasmon resonance wavelengths (520 and 630 nm) differ significantly.
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I. L. Maksimova, I. L. Maksimova, G. S. Terentyuk, G. S. Terentyuk, E. A. Genina, E. A. Genina, A. A. Skaptsov, A. A. Skaptsov, V. V. Tuchin, V. V. Tuchin, B. N. Khlebtsov, B. N. Khlebtsov, V. A. Bogatyrev, V. A. Bogatyrev, N. G. Khlebtsov, N. G. Khlebtsov, } "Diagnostic potentialities of plasmon-resonant nanoparticles as contrast agents for the diffuse back scattering spectroscopy of biotissues", Proc. SPIE 6536, Saratov Fall Meeting 2006: Coherent Optics of Ordered and Random Media VII, 65360C (20 June 2007); doi: 10.1117/12.753447; https://doi.org/10.1117/12.753447
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