22 May 2007 Design and simulation of interdigitated micro-electrode arrays for tumor cells separation and detection
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This work presents the design and simulations of an interdigitated micro-electrode array aimed to discriminate cancer cells, with potential applications in predictive oncology, diagnostics and anti-tumor drug research. The device has been designed and a technological fabrication process has been defined. The microsystem consists of a quartz substrate with gold electrodes and a microfabricated three-dimensional structure (glass/SU8) for cells confinement. The designed device consists of three separated part: two circular areas for confinement, detection and moving and a narrow channel between those areas for the transportation of the cells. The detection can be done by measuring the charge variations associated to the different membrane capacitances and conductivities of tumor and normal cells. Alternating electric field over the electrodes is used for moving the cells between the circular areas (Travelling Wave Dielectrophoresis TwDEP) as well as for levitating and trapping cells on the electrodes (positive-negative Dielectrophoresis p-nDEP). Analytical and Finite Elements simulations have been performed in order to verify the system reliability and to estimate the parameters in use, like operative frequency, voltage, expected velocity.
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Elisa Morganti, Elisa Morganti, Cristian Collini, Cristian Collini, Romina Cunaccia, Romina Cunaccia, Leandro Lorenzelli, Leandro Lorenzelli, } "Design and simulation of interdigitated micro-electrode arrays for tumor cells separation and detection", Proc. SPIE 6592, Bioengineered and Bioinspired Systems III, 65920O (22 May 2007); doi: 10.1117/12.724123; https://doi.org/10.1117/12.724123

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