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23 January 2007The influence of the protoporphyrin diamino acid derivatives photodynamic effect on the activity of selected enzymes
Photodynamic Therapy (PDT) requires three components: a dye applied as the photosensitizer, a source of light, and a
possibly large amount of oxygen dissolved in the tissue. The considerably higher absorption of porphyrin
photosensitizers by tumorous tissues allows the application of these photosensitizers in the diagnosis and therapy of
tumors. The cytotoxic and cytolethal effects of the photodynamic therapy are associated with the formation of a singlet
oxygen or production of radical species by the porphyrin photosensitizers. In the cell, the singlet oxygen or radical
species impair important macromolecules like membrane phospholipids, structural proteins, enzymes, and DNA. This
study describes the photodynamic effect of the PP(AA)2Arg2 group photosensitizers on the activity of adenosine
deaminase, DNA-ase and trypsin in relation to the photosensitizer dose and the excitation energy.
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Anna Romiszewska, Dariusz Pietrzykowski, Alfreda Graczyk, "The influence of the protoporphyrin diamino acid derivatives photodynamic effect on the activity of selected enzymes," Proc. SPIE 6598, Laser Technology VIII: Applications of Lasers, 659803 (23 January 2007); https://doi.org/10.1117/12.726525