Stochastic simulations of fatty-acid proto-cell models

F. Mavelli; K. Ruiz-Mirazo

doi:10.1117/12.724707

8 June 2007 Stochastic simulations of fatty-acid proto-cell models

F. Mavelli, K. Ruiz-Mirazo

Proceedings Volume 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems; 66021B (2007) https://doi.org/10.1117/12.724707
Event: SPIE Fourth International Symposium on Fluctuations and Noise, 2007, Florence, Italy

Abstract

In this contribution we tackle the problem of simulating the time behavior of self-assembling fatty acid vesicles in different experimental conditions. These systems have been (and are being) explored by various labs as possible precursor models of cellular compartments. By means of our recently developed stochastic simulation platform ('ENVIRONMENT') we are able to reproduce quite satisfactorily experimental data that have been reported on the different growth behavior of this type of proto-cellular systems, depending on the level of osmotic pressure they are under. The work here presented is part of a more general attempt to gain insight into the problem of how self-assembling vesicles (closed bilayer structures) could progressively turn into minimal self-producing and self-reproducing cells: i.e., into interesting candidates for (proto-)biological systems. This involves crossing the traditional gap between in silico and in vitro approaches, as we try to do here, convinced that major adavances in the field require the correct integration of both theoretical and experimental endeavors.

Citation Download Citation

F. Mavelli and K. Ruiz-Mirazo "Stochastic simulations of fatty-acid proto-cell models", Proc. SPIE 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, 66021B (8 June 2007); https://doi.org/10.1117/12.724707

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available