19 July 2007 Detection of early bronchial cancer by autofluorescence: results in patients with H&N cancer
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Abstract
Head and neck (H&N) cancer patients have a high incidence of second primary tumours in the tracheobronchial tree. Diagnostic autofluorescence bronchoscopy (DAFE) has shown promising results in the detection of early neoplastic and pre-neoplastic changes in the bronchi. We have investigated the medical impact of DAFE in a population of H&N cancer patients. The bronchoscopies were performed using a modified commercially available DAFE system. Endoscopic imaging of the tissue autofluorescence (AF) was combined with an online image analysis procedure allowing to discriminate between true and false positive results. White light (WL) bronchoscopy was performed as a control. Twenty-one patients with high lung cancer risk factors underwent WL and AF bronchoscopy with this improved system. Forty-one biopsies were taken on macroscopicall suspicious (WL or AF positive) sites. Seven patients were found to have second primary tumours in the bronchi. The sensitivity for the detection of these early lesions with the DAFE was 1.6 times larger than the sensitivity of WL bronchoscopy only. The positive predictive value (PPV) for AF is 79% (33% for WL alone). The PPV of both methods together is 100%. DAFE proved to be efficient for the detection of second primary lesions in H&N cancer patients and can be used as a simple addition to pre-operative work-up or follow-up in this patient population.
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Tanja Gabrecht, Tanja Gabrecht, Alexandre Radu, Alexandre Radu, Matthieu Zellweger, Matthieu Zellweger, Blaise Lovisa, Blaise Lovisa, Didier Goujon, Didier Goujon, Pierre Grosjean, Pierre Grosjean, Hubert van den Bergh, Hubert van den Bergh, Philippe Monnier, Philippe Monnier, Georges Wagnières, Georges Wagnières, } "Detection of early bronchial cancer by autofluorescence: results in patients with H&N cancer", Proc. SPIE 6628, Diagnostic Optical Spectroscopy in Biomedicine IV, 66280C (19 July 2007); doi: 10.1117/12.728247; https://doi.org/10.1117/12.728247
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