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19 July 2007 Semi-analytical method for rapid calculation of time-resolved reflectance from bi-layered tissue models
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Abstract
Photon transport in complex biological tissues is most accurately predicted via Monte Carlo (MC) modeling methods, which often require lengthy computation times. In this report, a semi-analytical technique (henceforth referred to as PI-scaling) was derived that combines MC simulation, absorption scaling, and path integrals (PI) to rapidly reconstruct time-resolved reflectance from the surface of bilayered epithelial tissue models. Comparisons to forward MC simulations indicated that the PI−scaling method was accurate to better than 10% for tissue models where the optical properties of the top layer did not greatly influence the time-resolved reflectance. Employing such a method should provide a novel solution to the first step of the problem of rapid simulation of time-resolved reflectance of photons in layered tissues.
© (2007) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Robert H. Wilson, Karthik Vishwanath, and Mary-Ann Mycek "Semi-analytical method for rapid calculation of time-resolved reflectance from bi-layered tissue models", Proc. SPIE 6628, Diagnostic Optical Spectroscopy in Biomedicine IV, 66280W (19 July 2007); https://doi.org/10.1117/12.729431
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