11 July 2007 Detection of abnormalities in tissues equivalent phantoms by multi-probe laser reflectometry
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The optical parameters of tissue-equivalent phantoms are determined by matching the normalized backscattering intensity (NBI) profiles iteratively with that obtained by Monte Carlo simulation procedure. Tissue equivalent optical phantoms (control and with abnormality) were prepared by mixing measured quantities of paraffin wax with wax colors. Abnormalities to be placed in the phantoms were prepared by controlling the absorption and scattering coefficients. The NBI profiles of the phantoms are obtained by an automatic non-contact scanning multi-probe laser reflectometer and are displayed as gray level images after processing. The NBI variations from the abnormality phantoms have distinct variations based on the optical characteristics of the abnormality embedded at various locations and depths. There is a considerable decrease or increase in the NBI variations for different detector probes based on the increase or decrease in absorption and scattering coefficients of abnormalities, respectively. From the profile of subtracted image the peak corresponds to the location of the abnormality and from the full width at half maximum the size of the abnormality is obtained. By further scanning of the image of the phantom with abnormality the depth of the embedded abnormality is obtained.
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P. S. Pandian, P. S. Pandian, M. Kumaravel, M. Kumaravel, Megha Singh, Megha Singh, "Detection of abnormalities in tissues equivalent phantoms by multi-probe laser reflectometry", Proc. SPIE 6628, Diagnostic Optical Spectroscopy in Biomedicine IV, 66281D (11 July 2007); doi: 10.1117/12.727886; https://doi.org/10.1117/12.727886

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