Pancreatic tissue assessment using fluorescence and reflectance spectroscopy

Malavika Chandra; David Heidt; Diane Simeone; Barbara McKenna; James Scheiman; Mary-Ann Mycek

doi:10.1117/12.729519

11 July 2007 Pancreatic tissue assessment using fluorescence and reflectance spectroscopy

Malavika Chandra, David Heidt, Diane Simeone, Barbara McKenna, James Scheiman, Mary-Ann Mycek

Proceedings Volume 6628, Diagnostic Optical Spectroscopy in Biomedicine IV; 66281R (2007) https://doi.org/10.1117/12.729519
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

The ability of multi-modal optical spectroscopy to detect signals from pancreatic tissue was demonstrated by studying human pancreatic cancer xenografts in mice and freshly excised human pancreatic tumor tissue. Measured optical spectra and fluorescence decays were correlated with tissue morphological and biochemical properties. The measured spectral features and decay times correlated well with expected pathological differences in normal, pancreatitis and adenocarcinoma tissue states. The observed differences between the fluorescence and reflectance properties of normal, pancreatitis and adenocarcinoma tissue indicate a possible application of multi-modal optical spectroscopy to differentiating between the three tissue classifications.

Citation Download Citation

Malavika Chandra, David Heidt, Diane Simeone, Barbara McKenna, James Scheiman, and Mary-Ann Mycek "Pancreatic tissue assessment using fluorescence and reflectance spectroscopy", Proc. SPIE 6628, Diagnostic Optical Spectroscopy in Biomedicine IV, 66281R (11 July 2007); https://doi.org/10.1117/12.729519

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