Gold nanorods: contrast agents for photoacoustic imaging?

C. Ungureanu; R. Raja Gopal; T. G. van Leeuwen; S. Manohar D.D.S.

doi:10.1117/12.728091

17 July 2007 Gold nanorods: contrast agents for photoacoustic imaging?

C. Ungureanu, R. Raja Gopal, T. G. van Leeuwen, S. Manohar D.D.S.

Proceedings Volume 6631, Novel Optical Instrumentation for Biomedical Applications III; 663108 (2007) https://doi.org/10.1117/12.728091
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

Gold nanorods are seen as possible contrast agents for photoacoustic imaging since they have strong absorption peaks at near-infrared wavelengths. Also they are easy to conjugate with various proteins. If these particles can be conjugated with cancer affinity proteins then these particles can accumulate specifically at a tumor site. By detecting the presence of accumulation of gold nanorods inside the tissue the indirect detection of tumor can be realized. When these particles are irradiated with light pulses of appropriate temporal properties and energy the temperature around these particles can be high enough to induce apoptosis or necrosis in the surrounding cells. In order to use these particles at their full potential we must determine precisely their optical properties. We simulated the optical properties of gold nanorods synthesized by us using the DDSCAT code. The simulated spectra agree qualitatively with the spectra determined using spectrometry and also determined using photoacoustic spectroscopy. Further the values of molar extinction coefficient derived from the simulations were similar to the data measured experimentally by other groups. These results validated qualitatively the model used in the simulations. During simulations we found that the choice of the dielectric function used in simulations plays an important role in the results.

Citation Download Citation

C. Ungureanu, R. Raja Gopal, T. G. van Leeuwen, and S. Manohar D.D.S. "Gold nanorods: contrast agents for photoacoustic imaging?", Proc. SPIE 6631, Novel Optical Instrumentation for Biomedical Applications III, 663108 (17 July 2007); https://doi.org/10.1117/12.728091

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available