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13 July 2007 Space-time modeling of the photon diffusion in a three-layered model: application to the study of muscular oxygenation
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Abstract
This work presents results on the modeling of the photon diffusion in a three-layered model, (skin, fat and muscle). The Finite Element method was performed in order to calculate the temporal response of the above-mentioned structure. The thickness of the fat layer was varied from 1 to 15 mm to investigate the effects of increasing fat thickness on the muscle layer absorption coefficient measurements for a source-detector spacing of 30 mm. The simulated time-resolved reflectance data, at different wavelengths, were fitted to the diffusion model to yield the scattering and absorption coefficients of muscle. The errors in estimating muscle absorption coefficients &mgr;α depend on the thickness of the fat layer and its optical properties. In addition, it was shown that it is possible to recover with a good precision (~2.6 % of error) the absorption coefficient of muscle and this up to a thickness of the fat layer not exceeding 4mm. Beyond this limit a correction is proposed in order to make measurements coherent. The muscle-corrected absorption coefficient can be then used to calculate hemoglobin oxygenation.
© (2007) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
C. Mansouri, J. P. L'Huillier, and V. Piron "Space-time modeling of the photon diffusion in a three-layered model: application to the study of muscular oxygenation", Proc. SPIE 6632, Therapeutic Laser Applications and Laser-Tissue Interactions III, 66320E (13 July 2007); https://doi.org/10.1117/12.728638
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