13 July 2007 Influence of choroidal perfusion on retinal temperature increase during retinal laser treatments
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In most retinal laser treatments the therapeutic effect is initiated by a transient temperature increase at and around the retinal pigment epithelium (RPE). Especially in long exposure time treatments like Transpupillary Thermotherapy (TTT) choroidal perfusion has a strong influence on the realized temperature at the fundus. The fundus blood circulation and therefore the heat dissipation is influenced by the intraocular pressure (IOP), which is investigated in the study presented here. In order to reduce the choroidal perfusion, the IOP is increased by injection of physiological saline solution into the eye of anaesthetized rabbits. The fundus is irradiated with 3.64 W/cm2 by means of a TTT-laser (λ = 810 nm) for t = 20 s causing a retinal temperature increase. Realtime temperature determination at the irradiated spot is achieved by a non invasive optoacoustic technique. Perfusion can be reduced by increasing IOP, which leads to different temperature increases when irradiating the retina. This should be considered for long time laser treatments.
© (2007) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Katharina Herrmann, Katharina Herrmann, Christian Flöhr, Christian Flöhr, Jens Stalljohann, Jens Stalljohann, Gabriela Apiou-Sbirlea, Gabriela Apiou-Sbirlea, Jochen Kandulla, Jochen Kandulla, Reginald Birngruber, Reginald Birngruber, Ralf Brinkmann, Ralf Brinkmann, } "Influence of choroidal perfusion on retinal temperature increase during retinal laser treatments", Proc. SPIE 6632, Therapeutic Laser Applications and Laser-Tissue Interactions III, 66321D (13 July 2007); doi: 10.1117/12.728222; https://doi.org/10.1117/12.728222

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