13 July 2007 High throughput high content live cell screening platform
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Abstract
The goal was to develop a light-microscope platform concept, which allows characterization of live cells in microtiter plates or in live-cell slide chambers with a speed, sensitivity and versatility unattainable so far. The goal was achieved by combining several novel technological concepts: a model-based digital control for a voice coil focus drive; scanner technology to follow a continuously moving sample during image acquisition, thus avoiding the usual stop-and-go; fast sectioning capabilities by using slit-scan confocal concepts; motorized dual emission image registration; and integrated environmental control.
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Rainer Uhl, Rainer Daum, Hartmann Harz, Christian Seebacher, Schomiron Neogy, "High throughput high content live cell screening platform", Proc. SPIE 6633, Biophotonics 2007: Optics in Life Science, 66330C (13 July 2007); doi: 10.1117/12.729545; https://doi.org/10.1117/12.729545
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