10 October 2007 In-situ optical detection of mesoscale components in glass microfluidic channel with monolithic waveguide
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Proceedings Volume 6715, Optomechatronic Actuators and Manipulation III; 67150H (2007) https://doi.org/10.1117/12.754395
Event: International Symposium on Optomechatronic Technologies, 2007, Lausanne, Switzerland
Abstract
Optical waveguides used as a local light source along a fluidic channel have proven to be an effective approach to detecting cells in the field of flow-cytometry. One challenge, however, has been a simple integration of optical waveguides with the fluidic channel. We employ the use of femtosecond laser-writing process to pattern a waveguide in the bulk of a fused-silica glass substrate housing a fluidic channel. We demonstrate an in-situ scheme for detecting sub-millimeter components based on such a monolithically fabricated device. By illuminating the waveguide and collecting the light signal past the channel, we detect opaque and transparent components between 300 - 500 μm in size, as each moves along the channel. Both an opaque square chip and a transparent bead attentuate the signal by more than 95% primarily due to reflection and refraction respectively. The signature of a transparent bead additionally shows attenuated peaks which we attribute to normal incidence of light from the waveguide. The projected sizes of the parts are determined with less than 1% uncertainty. We conclude that the femtosecond laser produced waveguides in fused-silica glass are a viable option for the detection of certain kinds of sub-millimeter components. This approach holds the prospects of fabricating complex three-dimensional networks of waveguides monolithically.
© (2007) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Vijay K. Pahilwani, Vijay K. Pahilwani, Yves Bellouard, Yves Bellouard, Ali A. Said, Ali A. Said, Mark Dugan, Mark Dugan, Philippe Bado, Philippe Bado, "In-situ optical detection of mesoscale components in glass microfluidic channel with monolithic waveguide", Proc. SPIE 6715, Optomechatronic Actuators and Manipulation III, 67150H (10 October 2007); doi: 10.1117/12.754395; https://doi.org/10.1117/12.754395
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