7 November 2007 Light-powered molecular engineering: a new technology for medical safety applications
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Abstract
We present a new photonic technology and demonstrate that it allows for precise immobilisation of biomolecules to sensor surfaces. The technology secures spatially controlled molecular immobilisation since immobilisation of each molecule to a support surface can be limited to the focal point of the ultraviolet (UV) beam, as small as a few micrometers. We can immobilise molecules according to any pattern, from classical microarrays to diffraction patterns creating unique watermarking safety patterns. Given that suitable protein markers exists for all relevant diseases it is entirely feasible to test for a range of disease indicators (antigens and other markers) in a single test. Few micrometer spotsize allows for a virtually unlimited number of protein spots in a multipotent microarray. This new technology produces radically new photonics based microarray sensing technology and watermarking and has clear potential for biomedical, bioelectronic, surface chemistry, security markers production, nanotechnology and therapeutical applications. We also show an in depth analyses of the immobilized patterns and of the microarrays with our software BNIP Pro.
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Maria Teresa Neves-Petersen, Maria Teresa Neves-Petersen, Meg Duroux, Meg Duroux, Esben Skovsen, Esben Skovsen, Laurent Duroux, Laurent Duroux, Steffen B. Petersen, Steffen B. Petersen, "Light-powered molecular engineering: a new technology for medical safety applications", Proc. SPIE 6739, Electro-Optical Remote Sensing, Detection, and Photonic Technologies and Their Applications, 67391A (7 November 2007); doi: 10.1117/12.737763; https://doi.org/10.1117/12.737763
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