9 June 2008 Optical monitoring of rheumatoid arthritis: Monte Carlo generated reconstruction kernels
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Proceedings Volume 6791, Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX; 67910G (2008) https://doi.org/10.1117/12.803975
Event: Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX, 2006, Saratov, Russian Federation
Abstract
Optical imaging in biomedicine is governed by the light absorption and scattering interaction on microscopic and macroscopic constituents in the medium. Therefore, light scattering characteristics of human tissue correlate with the stage of some diseases. In the near infrared range the scattering event with the coefficient approximately two orders of magnitude greater than absorption plays a dominant role. When measuring the optical parameters variations were discovered that correlate with the rheumatoid arthritis of a small joint. The potential of an experimental setup for transillumination the finger joint with a laser diode and the pattern of the stray light detection are demonstrated. The scattering caused by skin contains no useful information and it can be removed by a deconvolution technique to enhance the diagnostic value of this non-invasive optical method. Monte Carlo simulations ensure both the construction of the corresponding point spread function and both the theoretical verification of the stray light picture in rather complex geometry.
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O. Minet, O. Minet, J. Beuthan, J. Beuthan, A. H. Hielscher, A. H. Hielscher, U. Zabarylo, U. Zabarylo, } "Optical monitoring of rheumatoid arthritis: Monte Carlo generated reconstruction kernels", Proc. SPIE 6791, Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX, 67910G (9 June 2008); doi: 10.1117/12.803975; https://doi.org/10.1117/12.803975
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