Investigation of tissue oxygenation by in vivo laser-induced photodissociation of cutaneous arterial blood oxyhemoglobin

M. M. Asimov; A. N. Korolevich

doi:10.1117/12.803976

9 June 2008 Investigation of tissue oxygenation by in vivo laser-induced photodissociation of cutaneous arterial blood oxyhemoglobin

M. M. Asimov, A. N. Korolevich

Author Affiliations +

Proceedings Volume 6791, Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX; 67910H (2008) https://doi.org/10.1117/12.803976
Event: Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX, 2006, Saratov, Russian Federation

Abstract

A novel method of direct control of local tissue oxygenation based on laser-induced photodissociation of oxyhemoglobin in cutaneous blood vessels is discussed. New technology in selective and local increase of the concentration of free molecular oxygen in tissue that enhances metabolism of cells is demonstrated. Direct in vivo measurements of the tissue oxygen tension are carried out on human skin. Kinetics of oxygen tension in tissue is investigated under the effect of He-Ne laser radiation at the power of 1mW relatively to initial value of tissue oxygen tension. The results of experimental study the kinetics of oxygen distribution into tissue from arterial blood is presented. Biomedical applications of proposed new technology in laser therapy of pathologies where elimination of local tissue hypoxia is critical are discussed.

Citation Download Citation

M. M. Asimov and A. N. Korolevich "Investigation of tissue oxygenation by in vivo laser-induced photodissociation of cutaneous arterial blood oxyhemoglobin", Proc. SPIE 6791, Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX, 67910H (9 June 2008); https://doi.org/10.1117/12.803976

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