Toward single molecule detection through tip-enhanced near-field Raman spectroscopy

Prabhat Verma; Taro Ichimura; Taka-aki Yano; Yasushi Inouye; Satoshi Kawata

doi:10.1117/12.799265

3 April 2008 Toward single molecule detection through tip-enhanced near-field Raman spectroscopy

Prabhat Verma, Taro Ichimura, Taka-aki Yano, Yasushi Inouye, Satoshi Kawata

Proceedings Volume 6793, International Workshop and Conference on Photonics and Nanotechnology 2007; 67930H (2008) https://doi.org/10.1117/12.799265
Event: International Workshop and Conference on Photonics and Nanotechnology 2007, 2007, Pattaya, Thailand

Abstract

When Raman scattering is excited from the evanescent light field created by illuminating the apex of a sharp metallic nano-tip, it achieves new aspects with strong enhancement of scattering efficiencies and super resolving capabilities. The primary mechanism of tip-sample interaction is electromagnetic, which is based on the excitation of localized surface plasmon polaritons. However, when the tip is close enough to the sample, typically at molecular distances, the chemical interactions between the tip and the sample become important. Strong temporal fluctuations of Raman scattering, including fluctuations of peak frequencies and peak intensities, together with extraordinary enhancement of several peaks, were observed. These temporal fluctuations, which are typical signature of single molecule detection, were attributed to the changes of molecular orientations of the sample molecules in the upper layer of the nanocluster, which got chemically adsorbed at the tip molecules.

Citation Download Citation

Prabhat Verma, Taro Ichimura, Taka-aki Yano, Yasushi Inouye, and Satoshi Kawata "Toward single molecule detection through tip-enhanced near-field Raman spectroscopy", Proc. SPIE 6793, International Workshop and Conference on Photonics and Nanotechnology 2007, 67930H (3 April 2008); https://doi.org/10.1117/12.799265

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