Optical indicators of baseline blood status in dialysis patients

Neil S. Lagali; Kevin D. Burns; Deborah L. Zimmerman; Rejean Munger

doi:10.1117/12.778502

26 October 2007 Optical indicators of baseline blood status in dialysis patients

Neil S. Lagali, Kevin D. Burns, Deborah L. Zimmerman, Rejean Munger

Proceedings Volume 6796, Photonics North 2007; 679602 (2007) https://doi.org/10.1117/12.778502
Event: Photonics North 2007, 2007, Ottawa, Canada

Abstract

In a step towards the development of improved long-term prognostic indicators for patients with end-stage renal disease, we utilized absorption spectroscopy to determine the baseline status of whole blood in a cohort of 5 clinically-stable hemodialysis patients. The optical absorption spectrum of pre-dialysis and post-dialysis blood samples in the 400-1700nm wavelength range was measured for the cohort over a four-week period. Absorption spectra were consistent over time, with a maximum coefficient of variation (CV) of absorption under 2% (650-1650nm) for any given patient over the four-week period (pre and post-dialysis). Spectra varied by a greater amount across patients, with a maximum CV of 5% in any given week. Analysis of variance indicated a broad spectral range (650-1400nm) where within-patient spectral variation was significantly less than between-patient variation (p<0.001), providing the potential for development of stable baseline blood status indicators. The spectra were investigated using principal component analysis (PCA) including a further set of whole blood absorption spectra obtained from 4 peritoneal dialysis patients. PCA revealed the fingerprint-like nature of the blood spectrum, an overall similarity of the spectrum within each treatment mode (hemodialysis or peritoneal dialysis), and a distinct spectral difference between the treatment modes.

Citation Download Citation

Neil S. Lagali, Kevin D. Burns, Deborah L. Zimmerman, and Rejean Munger "Optical indicators of baseline blood status in dialysis patients", Proc. SPIE 6796, Photonics North 2007, 679602 (26 October 2007); https://doi.org/10.1117/12.778502

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Blood

Absorption

Principal component analysis

Oxygen

Statistical analysis

Ocean optics

Urea

Show All Keywords

Keywords/Phrases

Search In:

Publication Years