Design and fabrication of polymer microfluidic chip for ESI-MS

Sana Malahat; Pio Iovenitti; Igor Sbarski

doi:10.1117/12.768447

27 December 2007 Design and fabrication of polymer microfluidic chip for ESI-MS

Sana Malahat, Pio Iovenitti, Igor Sbarski

Proceedings Volume 6799, BioMEMS and Nanotechnology III; 679910 (2007) https://doi.org/10.1117/12.768447
Event: SPIE Microelectronics, MEMS, and Nanotechnology, 2007, Canberra, ACT, Australia

Abstract

In this paper, we report on the design, fabrication, and testing of a polymer micro fluidic chip for Electrospray Ionization Mass Spectrometry (ESI-MS). A disposable plastic chip is designed to be fabricated using the hot-embossing process on polystyrene (PS) and polycarbonate (PC) substrates. The chip has an open reservoir, which is connected to an open channel that runs to the tip of the chip. A high voltage circuit is required to form the electrospray at the tip using methanol/water solution with an electrode wire in the reservoir. We have tried to minimize sources of impurities entering the microchannel, and hence, the MS, by careful selection of the fabrication process and electrode and use of open channel. The hot-embossing process is modeled using ANSYS to design the tool and predict the channel and reservoir shape and deformation. The simulation results provide an insight into the hot embossing process. Several samples are fabricated and tested, and the electrospray experimental results are reported. Laser machining and electroforming processes were investigated for fabricating the hot-embossing tool, and the results are reported.

Citation Download Citation

Sana Malahat, Pio Iovenitti, and Igor Sbarski "Design and fabrication of polymer microfluidic chip for ESI-MS", Proc. SPIE 6799, BioMEMS and Nanotechnology III, 679910 (27 December 2007); https://doi.org/10.1117/12.768447

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