Translator Disclaimer
27 December 2007 Design and fabrication of polymer microfluidic chip for ESI-MS
Author Affiliations +
Abstract
In this paper, we report on the design, fabrication, and testing of a polymer micro fluidic chip for Electrospray Ionization Mass Spectrometry (ESI-MS). A disposable plastic chip is designed to be fabricated using the hot-embossing process on polystyrene (PS) and polycarbonate (PC) substrates. The chip has an open reservoir, which is connected to an open channel that runs to the tip of the chip. A high voltage circuit is required to form the electrospray at the tip using methanol/water solution with an electrode wire in the reservoir. We have tried to minimize sources of impurities entering the microchannel, and hence, the MS, by careful selection of the fabrication process and electrode and use of open channel. The hot-embossing process is modeled using ANSYS to design the tool and predict the channel and reservoir shape and deformation. The simulation results provide an insight into the hot embossing process. Several samples are fabricated and tested, and the electrospray experimental results are reported. Laser machining and electroforming processes were investigated for fabricating the hot-embossing tool, and the results are reported.
© (2007) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Sana Malahat, Pio Iovenitti, and Igor Sbarski "Design and fabrication of polymer microfluidic chip for ESI-MS", Proc. SPIE 6799, BioMEMS and Nanotechnology III, 679910 (27 December 2007); https://doi.org/10.1117/12.768447
PROCEEDINGS
12 PAGES


SHARE
Advertisement
Advertisement
RELATED CONTENT

OSTE: a new material system for labs-on-chip
Proceedings of SPIE (March 05 2014)
3D-CSP: an innovative packaging method based on RMPD
Proceedings of SPIE (April 29 2001)
An integrated biochip design and fabrication
Proceedings of SPIE (November 12 2002)

Back to Top